Science House is located in on East 38th Street between Park and Lexington in Manhattan. The building has a long history of innovation, starting with the very first brick. It was originally built by an innovative entrepreneur who founded a clothing company that created money back guarantees and tags listing the materials used. He then sold the building to Abraham Lincoln's granddaughter, Mary Lincoln Isham, who lived here with her family for 35 years. It has now been redesigned as a cathedral of the imagination by co-directors James Jorasch and Rita J. King.

Science House clients can book the venue for teams of up to 20 people. Teams can have an offsite, brainstorming session, workshop or group work on any shared problem.